Antioxidant Activity and Toxicity Study of Cerium Oxide Nanoparticles Stabilized with Innovative Functional Copolymers

Oxidative stress, which is one of the main harmful mechanisms pathologies including ischemic stroke, contributes to both neurons and endothelial cell damages, leading vascular lesions. Although many antioxidants are tested in preclinical studies, no treatment currently available for stroke patients. Since cerium oxide nanoparticles (CNPs) exhibit remarkable antioxidant capacities, objective develop an innovative coating enhance CNPs biocompatibility without disrupting their capacities or toxicity. This study reports synthesis characterization functional polymers impact on enzyme-like catalytic activity CNPs. To toxicity properties particularly vitro studies conducted a cerebral line (bEnd.3). Despite internalization bEnd.3 cells, coated devoid cytotoxicity. Microscopy report intracellular localization CNPs, more precisely endosomes. All reduces glutamate-induced production reactive oxygen species (ROS) cells but CNP significantly mitochondrial superoxide anion DNA oxidation. In vivo lack mice. therefore describes identifies biocompatible with interesting related pathologies.